2013年06月28日
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The RANKL activity is antagonised by a soluble decoy receptor osteoprotegerin (OPG), which is also expressed by osteoblasts and stromal cells. Local RANKL ratio determines the osteoclastogenic potential. Binding of RANKL to RANK expressed on osteoclast precursors activates nuclear factor and Jun Nterminal kinase pathways to induce differentiation (Boyle et al, 2003).
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